Understanding the Challenges in Formulating Adhesives for Transdermal Drug Delivery

9/1/10

Understanding the Challenges in Formulating Adhesives for Transdermal Drug Delivery
Transdermal, September 2010

As transdermal drug delivery systems (TDDS) evolve to deliver a wider scope of treatments through the skin, adhesives manufacturers are facing even more challenges in formulating compatible adhesives that are functional, precise, and safe. The science of formulating adhesives for TDDS requires a careful balance; that is, the adhesive must deliver functionality while it also provides a safe format. The adhesive must be compatible both with the active pharmaceutical ingredients (APIs) and with the patient’s skin and must deliver a reliable and reproducible therapeutic dose.

This article discusses some of the specific bonding and dermatologic challenges that need to be considered when formulating the highly specialized adhesive chemistries that are required of current transdermal drug delivery systems.