Challenges of Formulating Adhesives for Transdermal Drug Delivery Systems


Transdermal Technology
By: John O’Mahony
Pharmaceutical Manufacturing and Packing Sourcer
May 2009

Transdermal drug delivery systems (TDDS) are widely proven and accepted forms for predictable and reproducible drug delivery.  TDDS bypass the hepatic first-pass effect and potential gastrointestinal side effects of oral dosage forms, as the drug is absorbed directly through the skin for delivery to the blood or lymphatic system. Treatment is quickly and easily terminated if toxicities (such as drug allergies) occur, simply by removing the patch. This drug delivery platform improves patient compliance for chronic or maintenance treatments by virtue of its ease of use, fewer side effects, relatively low cost in comparison to alternative devices, and minimal risk of trauma or infection.